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A scanning electron microscopic study of Reissner's fibre in elderly mice
Abstract:
Reissner's fibre was investigated in brains and cervical spinal cords of mice aged 28 and 31 months using scanning electron microscopy. At both 28 and 31 months Reissner's fibre was present. It arose from a fusing together of numerous smaller fibres in the subcommissural organ and was observed in the aqueduct, fourth ventricle and central canal of the medulla and spinal cord. For most of its length it was a ridged structure similar to a stick of celery but in places small processes could be seen arising from its surface. Cilia, supraependymal cells and other debris appeared to be adherent to the fibre and this may support the view that Reissner's fibre has a detoxifying function which is still present in old age.
Insights
Reissner's fibre, a structure in the brain and spinal cord, was observed in old mice. This finding suggests its potential detoxifying function persists into old age.
Area of Science:
- Neuroscience
- Histology
- Gerontology
Background:
- Reissner's fibre is a poorly understood structure found in the cerebrospinal fluid pathways.
- Its function, particularly in aging organisms, remains largely unelucidated.
Purpose of the Study:
- To investigate the presence and morphology of Reissner's fibre in aged mice.
- To explore potential functional implications of Reissner's fibre in old age.
Main Methods:
- Scanning electron microscopy was employed to examine the brains and cervical spinal cords of mice at 28 and 31 months of age.
- Detailed morphological analysis of Reissner's fibre was conducted within the ventricular and central canal systems.
Main Results:
- Reissner's fibre was consistently present in the aqueduct, fourth ventricle, and central canal of aged mice.
- The fibre exhibited a ridged structure, with some areas showing small surface processes.
- Debris, including cilia and supraependymal cells, adhered to the fibre.
Conclusions:
- Reissner's fibre is present and retains its structural characteristics in aged mice.
- The observed adherence of cellular debris suggests a potential ongoing detoxifying role for Reissner's fibre in old age.