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Circulating androgens in male acne.

H L van der Meeren, J H Thijssen

The British Journal of Dermatology

|May 1, 1984

Summary

This study found no significant differences in key hormone levels, including testosterone and dehydroepiandrosterone sulfate, between men with severe acne and control groups. These hormonal markers do not appear to be distinguishing factors for severe acne in men.

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Area of Science:

Endocrinology
Dermatology
Andrology

Background:

Severe acne affects a significant portion of the male population.
Hormonal imbalances, particularly androgens, are often implicated in acne pathogenesis.
Previous research has yielded conflicting results regarding specific hormone levels in acne patients.

Purpose of the Study:

To investigate the association between specific serum hormone levels and severe acne in men.
To compare the levels of total testosterone, free testosterone, sex hormone binding globulin, albumin, and dehydroepiandrosterone sulfate in men with and without severe acne.

Main Methods:

Serum samples were collected from 35 men diagnosed with severe acne.
Hormone levels including total testosterone, free testosterone, sex hormone binding globulin (SHBG), albumin, and dehydroepiandrosterone sulfate (DHEAS) were quantified.
Measurements were compared between the severe acne cohort and a control group.

Main Results:

No statistically significant differences were observed in total serum testosterone levels between patients and controls.
Free testosterone levels did not show a striking difference between the severe acne group and the control group.
Levels of sex hormone binding globulin, albumin, and dehydroepiandrosterone sulfate were comparable in both groups.

Conclusions:

The findings suggest that common hormonal markers, including androgens like testosterone and DHEAS, are not significantly altered in men with severe acne.
This study indicates that severe acne in men may not be directly driven by the measured systemic hormonal variations.
Further research may be needed to explore other potential etiological factors in severe acne development.

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