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Local venous infusion of streptokinase in DVT

S Schulman, D Lockner

    Thrombosis Research
    |May 1, 1984
    PubMed

    Insights

    Local venous streptokinase (SK) infusion for thigh deep vein thrombosis (DVT) showed limited efficacy and side effects. The lowest dose had minimal effect, suggesting no advantage over systemic therapy for DVT treatment.

    Area of Science:

    • Vascular Medicine
    • Thrombosis Research
    • Pharmacology

    Background:

    • Deep vein thrombosis (DVT) is a significant vascular condition requiring effective treatment.
    • Thrombolytic therapy aims to dissolve blood clots, but its optimal delivery method for DVT remains under investigation.
    • Streptokinase (SK) is a thrombolytic agent with potential applications in DVT management.

    Purpose of the Study:

    • To evaluate the efficacy and safety of local venous streptokinase (SK) infusion for acute deep vein thrombosis (DVT) of the thigh.
    • To determine the optimal dose and duration for local SK infusion in DVT treatment.
    • To compare the effectiveness and side effect profile of local venous SK infusion versus systemic SK therapy.

    Main Methods:

    • Fourteen patients with acute thigh DVT were enrolled.
    • Treatment involved local venous infusion of varying streptokinase (SK) doses.
    • The lowest effective dose was identified as 4,000 U/h for 72 hours.

    Main Results:

    • Only the lowest SK dose (4,000 U/h for 72 h) demonstrated significant thrombolysis in 3 out of 9 patients.
    • Systemic hemorrhagic side effects were observed in 3 patients.
    • Local dermatitis occurred in 3 patients, indicating adverse reactions to the infusion.

    Conclusions:

    • Local venous SK infusion for thigh DVT shows limited efficacy and carries risks of systemic and local side effects.
    • The catheter placement and collateral circulation may hinder effective thrombolysis.
    • There is likely no significant advantage of local venous SK infusion over systemic SK therapy for DVT.

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