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Mitogenicity of cell wall fractions of Micropolyspora faeni
Annals of Allergy
|January 1, 1978
Abstract:
Cell wall fractions of Micropolyspora faeni, a causative agent of hypersensitivity pneumonitis, have been shown to possess non-specific mitogenic activity for guinea pig, rabbit and human lymphocytes. This activity was unrelated to endotoxin and may not be associated with peptidoglycan. This lymphocyte proliferation stimulus may play a role in the adjuvant properties of this organism and in the etiology of hypersensitivity lung disease.
Insights
Cell wall components from Micropolyspora faeni stimulate lymphocyte proliferation in multiple species. This immune response may contribute to hypersensitivity pneumonitis and the organism's adjuvant effects.
Area of Science:
- Immunology
- Microbiology
- Pulmonary Medicine
Background:
- Micropolyspora faeni is linked to hypersensitivity pneumonitis.
- Cell wall components are potential immune modulators.
Purpose of the Study:
- To investigate the mitogenic activity of Micropolyspora faeni cell wall fractions.
- To determine the role of these fractions in immune responses and disease etiology.
Main Methods:
- Extraction of cell wall fractions from Micropolyspora faeni.
- Assaying mitogenic activity on lymphocytes from guinea pigs, rabbits, and humans.
Main Results:
- Cell wall fractions demonstrated non-specific mitogenic activity.
- This activity was independent of endotoxin and likely not due to peptidoglycan.
Conclusions:
- Micropolyspora faeni cell wall components stimulate lymphocyte proliferation.
- This stimulation may contribute to the adjuvant properties and hypersensitivity lung disease caused by this organism.