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Published on: August 22, 2017
Norfloxacin--a review of pharmacology and tissue penetration
Abstract:
A review of the pharmacokinetics of the highly active quinoline derivative, norfloxacin, is presented. The compound appears to be rapidly absorbed. The serum half-life is about 3 X 5 h and 30% of a given dose is recovered in the urine. Rapid penetration of an inflammatory exudate occurs. The compound is metabolized to a modest extent, probably in the liver, six metabolites being recognized. The serum half-life is prolonged in severe renal impairment. Probenecid would appear to decrease the renal elimination. The possibility of treating both urinary and tissue infections with this compound is raised.
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