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Metabolic and contractile function enhancement during rat heart postnatal development.

R T Dowell

    Mechanisms of Ageing and Development
    |June 1, 1984
    PubMed
    Summary

    Postnatal heart growth in mammals enhances cardiac function through increased cell numbers and mitochondrial mass. Myofibrillar ATPase activity also doubles, supporting improved contractility during development.

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    Area of Science:

    • Physiology
    • Biochemistry
    • Developmental Biology

    Background:

    • Enhanced cardiac contractile function is a key mammalian trait post-birth.
    • Systematic metabolic measurements during postnatal heart development are lacking.

    Purpose of the Study:

    • To define postnatal heart development in rats.
    • To correlate cardiac function with metabolic and enzymatic changes.

    Main Methods:

    • Measured left ventricular pressure and dP/dt in rats from 3 to 9 weeks post-birth.
    • Analyzed heart weight, DNA content, and enzyme activities (glycolytic, aerobic, ATPase).

    Main Results:

    • Left ventricular weight increased 5-fold, body weight 8-fold.
    • Mitochondrial mass (citrate synthase, malate dehydrogenase) increased 6-fold, outpacing tissue growth.

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  • Myofibrillar ATPase activity doubled, correlating with enhanced contractile function.

    • Conclusions:

    • Postnatal heart growth involves coordinated increases in cell number, mitochondrial mass, and myofibrillar ATPase activity.
    • Aerobic metabolism capacity significantly increases to support developing cardiac function.
    • Enhanced cardiac contractility is supported by increased mitochondrial accumulation and myofibrillar ATPase activity.