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Bilateral trunkal vagotomy (BTV) regarded as a pathogenic process. An experimental study.
Morphologie Et Embryologie
|April 1, 1984
Summary
Bilateral trunkal vagotomy (BTV) causes early gastric mucosal damage, including blood stasis and inflammation. Chronic changes like intestinal metaplasia appear months later, indicating long-term effects of vagal nerve disruption.
Area of Science:
- Gastroenterology
- Surgical Pathology
- Vascular Biology
Background:
- Bilateral trunkal vagotomy (BTV) is a surgical procedure impacting gastric function.
- Understanding the temporal sequence of gastric mucosal changes post-BTV is crucial for clinical management.
Purpose of the Study:
- To investigate the acute and chronic pathological modifications in the gastric mucosa following bilateral trunkal vagotomy (BTV).
Main Methods:
- Surgical induction of bilateral trunkal vagotomy (BTV) in an experimental model.
- Histopathological examination of gastric mucosal tissues at various time points (14 days, 2 and 3 months post-surgery).
Main Results:
- Acute phase (first 14 days): Characterized by vascular lesions (blood stasis, thrombosis) preceding gastric mucosal damage (inflammation, necrobiosis).
- Chronic phase (2-3 months): Revealed persistent inflammation and the development of intestinal metaplasia in the gastric mucosa.
Conclusions:
- BTV induces a cascade of gastric mucosal changes, initiating with vascular compromise and progressing to chronic inflammatory and metaplastic alterations.
- The findings highlight the significant and long-lasting pathological impact of vagotomy on gastric tissue.