Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Probenecid-induced norepinephrine elevations in plasma and CSF.

C R Lake, J H Wood, M G Ziegler

    Archives of General Psychiatry
    |February 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Psychosis in an adolescent patient with Wilson's disease: effects of chelation therapy.

    Psychosomatic medicine·1995
    Same author

    Hypercortisolemia inhibits yohimbine-induced release of norepinephrine in the posterolateral hypothalamus of conscious rats.

    Endocrinology·1992
    Same author

    Noradrenergic activation in the paraventricular nucleus during acute and chronic immobilization stress in rats: an in vivo microdialysis study.

    Brain research·1992
    Same author

    Sympathoadrenal contribution to plasma dopa (3,4-dihydroxyphenylalanine) in rats.

    Clinical science (London, England : 1979)·1992
    Same author

    Regulation of tyrosine hydroxylase and dopamine beta-hydroxylase mRNA levels in rat adrenals by a single and repeated immobilization stress.

    Journal of neurochemistry·1992
    Same author

    Effects of handling or immobilization on plasma levels of 3,4-dihydroxyphenylalanine, catecholamines, and metabolites in rats.

    Journal of neurochemistry·1992
    Same journal

    Reviewers Who Completed a Review During 2011.

    Archives of general psychiatry·2017
    Same journal

    Conflicts of interest-reply.

    Archives of general psychiatry·2013
    Same journal

    Epidemiologic evidence concerning the bereavement exclusion in major depression-reply.

    Archives of general psychiatry·2013
    Same journal

    This month in archives of general psychiatry.

    Archives of general psychiatry·2013
    Same journal

    About this journal.

    Archives of general psychiatry·2013
    Same journal

    This month in archives of general psychiatry.

    Archives of general psychiatry·2013
    See all related articles

    High doses of probenecid increase norepinephrine (NE) in plasma and cerebrospinal fluid (CSF), potentially by triggering its release from neurons. Side effects like nausea correlated with lower drug and NE levels.

    Area of Science:

    • Neuroscience
    • Pharmacology

    Background:

    • Norepinephrine (NE) is a crucial neurotransmitter involved in various physiological processes.
    • Probenecid is a uricosuric agent that inhibits organic anion transporters.

    Purpose of the Study:

    • To investigate the effect of probenecid on norepinephrine levels in plasma and cerebrospinal fluid (CSF).
    • To explore the relationship between probenecid dosage, NE levels, and adverse effects.

    Main Methods:

    • Oral administration of probenecid at 100 mg/kg in divided doses.
    • Measurement of NE levels in plasma and CSF.
    • Analysis of 3-methoxy-4-hydroxy-phenylethyleneglycol (MHPG) levels.
    • Correlation of probenecid and NE levels with patient-reported symptoms (nausea, vomiting).

    Related Experiment Videos

    Main Results:

    • Probenecid administration significantly increased NE levels in both plasma and CSF.
    • Elevated levels of the NE metabolite MHPG were observed, suggesting increased NE turnover.
    • Patients experiencing nausea or vomiting had lower CSF probenecid and plasma NE levels, indicating impaired absorption and a potential link to side effects.

    Conclusions:

    • High-dose probenecid administration can increase norepinephrine levels, likely through enhanced release from noradrenergic neurons.
    • Reduced absorption of probenecid may be associated with gastrointestinal side effects and lower systemic NE levels.