Potentiation of teratogenesis

Teratology studies were conducted with rats on Days 10 or 12 of gestation using combinations of a variety of agents including inhibitors of DNA, RNA, protein, and purine synthesis. With the exception of administration of pairs of DNA inhibitors, most combinations showed potentiation of embryolethality and teratogenesis as compared to that seen with the use of the individual agents. In conjunction with earlier studies with caffeine, acetazolamide, and other agents, it is seen that combinations of a wide variety of agents can interact to potentiate embryolethality and teratogenesis.