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TRH test abnormalities in psychiatric disorders.

A Wolkin, E D Peselow, M Smith

    Journal of Affective Disorders
    |June 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

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    Thyrotropin-releasing hormone (TRH) stimulation tests, previously thought to distinguish depression from schizophrenia, were abnormal in both patient groups. This endocrine test lacks diagnostic utility for differentiating these psychiatric disorders.

    Area of Science:

    • Neuroendocrinology
    • Psychiatry
    • Clinical Psychology

    Background:

    • Blunted thyrotropin-releasing hormone (TRH) stimulation responses are common in depression and other affective disorders.
    • TRH tests have generally shown normal results in schizophrenic patients, suggesting potential diagnostic value.

    Purpose of the Study:

    • To investigate the diagnostic and symptom specificity of the TRH stimulation test.
    • To determine if the TRH test can differentiate schizophrenia from affective disorders.

    Main Methods:

    • A sample of 51 subjects, including 17 with schizophrenia, underwent TRH stimulation testing.
    • Psychopathology ratings were collected for all participants.

    Main Results:

    • Abnormal TRH stimulation tests were observed in both schizophrenic and affectively disturbed patients.

    Related Experiment Videos

  • No significant correlations were found between TRH test results and depression ratings or other psychopathological symptoms.

    • Conclusions:

    • The TRH stimulation test does not appear to have diagnostic utility in distinguishing schizophrenia from affective disorders.
    • Abnormalities in TRH response are present in both conditions, challenging previous assumptions.