Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neonatal paroxysmal monorhythmic alpha activity.

T A Knauss, C B Carlson

    Archives of Neurology
    |February 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Neonatal seizures can manifest as rhythmic alpha brainwaves in the rolandic cortex. This pattern, linked to cortical atrophy and neurological issues, suggests encephalomalacia may cause these infant seizures.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Structures of thrombospondins.

    Cellular and molecular life sciences : CMLS·2008
    Same author

    Solid-phase synthesis of acridine-based threading intercalator peptides.

    Bioorganic & medicinal chemistry letters·2000
    Same author

    Solid-phase synthesis of acridine-peptide conjugates and their analysis by tandem mass spectrometry.

    Organic letters·2000
    Same author

    Video game-related seizures: a report on 10 patients and a review of the literature.

    Pediatrics·1994
    Same author

    X-linked adrenoleukodystrophy: adult cerebral variant.

    Neurology·1993
    Same author

    Antidepressants and convulsions.

    Journal of clinical psychopharmacology·1992
    Same journal

    Incorrect Table Entries and Word.

    Archives of neurology·2016
    Same journal

    IDEAL for CCSVI Research-Reply.

    Archives of neurology·2013
    Same journal

    Atlas of Inherited Metabolic Diseases, 3rd ed.

    Archives of neurology·2013
    Same journal

    Error in byline: in heterogeneity of coenzyme q10 deficiency: patient study and literature review.

    Archives of neurology·2013
    Same journal

    This month in archives of neurology.

    Archives of neurology·2013
    Same journal

    About this journal.

    Archives of neurology·2013
    See all related articles

    Area of Science:

    • Neonatal neurology
    • Epileptology
    • Neuroimaging

    Background:

    • Neonatal seizures are a critical concern in infant neurology.
    • Electrographic seizure activity in neonates requires precise characterization.
    • The specific electroencephalographic (EEG) patterns and their correlation with outcomes are actively researched.

    Purpose of the Study:

    • To investigate the characteristics of paroxysmal monorhythmic alpha activity in neonatal seizures.
    • To correlate these electrographic findings with clinical seizures and neuroimaging results.
    • To explore the potential role of encephalomalacia in the pathogenesis of these seizures.

    Main Methods:

    • Analysis of electroencephalographic (EEG) data from thirteen infants with neonatal seizures.

    Related Experiment Videos

  • Clinical observation of seizure activity.
  • Computerized tomography (CT) scans performed weeks after electrographic abnormalities were detected.
  • Correlation of EEG findings with neurological examinations and head circumference measurements.

    • Main Results:

    • Thirteen infants exhibited paroxysmal monorhythmic electrographic activity, primarily in the alpha range (8-13 Hz), localized to rolandic cortical areas.
    • This activity was often lateralized and associated with clinically observed seizures.
    • In most cases (8/13), independent epileptiform discharges were also present.
    • CT scans revealed diffuse or localized cortical atrophy mirroring the EEG abnormality.
    • Focal neurological deficits and microcephaly were observed in infants with localized monorhythmic alpha activity.

    Conclusions:

    • Paroxysmal monorhythmic alpha activity represents a distinct electrographic seizure discharge in neonates.
    • The findings suggest a strong association between this EEG pattern, cortical atrophy, and focal neurological abnormalities.
    • Encephalomalacia is proposed as a significant factor in the pathogenesis of these neonatal seizures.