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Genetic amniocentesis in multiple gestations.

K Filkins, J Russo, T Brown

    Prenatal Diagnosis
    |May 1, 1984
    PubMed
    Summary
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    Genetic amniocentesis in multiple gestations, including triplets, demonstrated successful fetal genetic sampling. While some complications occurred, cases of trisomy 21 discordance showed varied outcomes, with triplets remaining healthy.

    Area of Science:

    • Medical Genetics
    • Maternal-Fetal Medicine
    • Prenatal Diagnosis

    Background:

    • Multiple gestations present unique challenges for prenatal diagnosis.
    • Genetic amniocentesis is a key procedure for assessing fetal genetic health.

    Purpose of the Study:

    • To evaluate the safety and efficacy of genetic amniocentesis in multiple gestations.
    • To analyze outcomes of pregnancies undergoing genetic amniocentesis for twins and triplets.

    Main Methods:

    • Real-time ultrasonography was utilized to precisely locate amniotic sacs.
    • Genetic amniocentesis was performed on thirty-one multiple gestations between 1976 and 1982.
    • Outcomes including spontaneous abortions, therapeutic abortions, and genetic anomaly discordance were recorded.

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    Main Results:

    • Successful genetic sampling was achieved in all cases.
    • Spontaneous abortions occurred in two twin and one triplet gestation.
    • Two cases of twin and triplet pregnancies with discordant trisomy 21 were managed, with differing neonatal outcomes.

    Conclusions:

    • Genetic amniocentesis is technically feasible in multiple gestations, including triplets.
    • Pregnancy outcomes are influenced by gestational factors and specific genetic conditions like trisomy 21.
    • Careful monitoring and management are crucial for discordant genetic findings in multiple pregnancies.