Related Experiment Video
Updated: Aug 27, 2026

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
Published on: December 30, 2016
T-cell effects on in vitro erythropoiesis: immune regulation and immune reactivity
Abstract:
Optimal in vitro growth of BFU-E requires factors or burst promoting activities (BPA) in addition to erythropoietin. Our studies suggest that small numbers of DR-haploidentical T cells and monocytes present in plasma clot cultures of peripheral blood mononuclear cells can elaborate a BPA in situ. Various populations of normal T cells can augment or limit this activity. In addition, allosensitized "immune-reactive" T cells can inhibit this activity in both a genetically restricted and nonrestricted manner. With this in mind, it becomes important to consider that inhibition of BFU-E growth growth does not necessarily evoke lymphocytes reactive against BFU-E, but rather lymphocytes that can interfere with regulation of auxiliary cell function. Whether or not faulty immune regulation plays a role in "immune-mediated" aplasia remains to be determined.
Related Concept Videos
Cell-mediated Immune Responses
Regulation of Hematopoietic Stem Cells
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Factors Affecting Erythropoiesis
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...

