[Antiepileptic effects of synthetic pharmacologic agents and vitamin preparations used in combination]

The effects of synthetic antiepileptic drugs (phenobarbital and diazepam) and vitamins (nicotinamide, pyridoxal-5 phosphate and alpha-tocopherol) were investigated on the model of the chronically epileptized brain in the form of corasole kindling in inbred and noninbred mice. It has been shown that both series of drugs inhibit the epileptic activity developing at the peak of brain epileptization and prevent its further development. The results of the study demonstrate the benefit of the multimodality pathogenetic therapy of epilepsy and suggest the advisability of its practical application.