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Safety profile: fifteen years of clinical experience with ibuprofen
Abstract:
Since its introduction in the United States in 1974, ibuprofen (Motrin, Upjohn) has been shown to be safe and effective for the treatment of pain, dysmenorrhea, inflammation, and fever. A careful review of pre-registration and postmarketing data from both patients and normal subjects clearly indicates ibuprofen's remarkable safety profile compared with that of aspirin and other commonly prescribed nonsteroidal anti-inflammatory agents. Continued safety can be anticipated on the basis of the past 15 years of review experience.
Insights
Ibuprofen is a safe and effective medication for pain, inflammation, and fever. Its safety profile is superior to aspirin and other nonsteroidal anti-inflammatory drugs.
Area of Science:
- Pharmacology
- Drug Safety
Background:
- Ibuprofen, introduced in 1974, is widely used for pain, dysmenorrhea, inflammation, and fever.
- Nonsteroidal anti-inflammatory agents (NSAIDs) are common treatments for various conditions.
Purpose of the Study:
- To evaluate the safety profile of ibuprofen.
- To compare ibuprofen's safety with aspirin and other NSAIDs.
Main Methods:
- Review of pre-registration data.
- Analysis of postmarketing data from patients and healthy subjects.
Main Results:
- Ibuprofen demonstrates a remarkable safety profile.
- Ibuprofen's safety is superior when compared to aspirin and other NSAIDs.
Conclusions:
- Ibuprofen is a safe and effective therapeutic agent.
- Continued safety of ibuprofen is anticipated based on extensive review experience.