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Five patients with iodine-induced hyperthyroidism.

R Rajatanavin, M Safran, W A Stoller

    The American Journal of Medicine
    |August 1, 1984
    PubMed
    Summary
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    Iodine exposure from common medications can trigger hyperthyroidism (overactive thyroid), even in iodine-sufficient areas. This condition often resolves after stopping iodine intake, especially in patients with multinodular goiters.

    Area of Science:

    • Endocrinology
    • Thyroidology

    Background:

    • Iodine-induced hyperthyroidism is recognized in iodine-deficient regions.
    • It can also affect individuals in iodine-sufficient areas, with or without pre-existing thyroid conditions.

    Observation:

    • Five cases of iodine-induced hyperthyroidism were observed over 12 months.
    • Patients had exposure to iodine via common medications like Betadine, Iodo-Niacin, amiodarone, and radiographic contrast dyes.

    Findings:

    • The exact cause remains unclear, but it may be linked to goiters with autonomous function or iodine-poor thyroglobulin.
    • Hyperthyroidism typically resolves upon iodine withdrawal in patients with multinodular goiters or normal thyroid glands.

    Implications:

    • Treatment involves beta-blockers and antithyroid drugs; iodine blockade or corticosteroids may be needed occasionally.

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  • Caution is advised when administering iodine-containing drugs to individuals with underlying thyroid disease.