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Quantitative aspects of membrane shifts in rat parathyroid cells initiated by decrease in serum calcium.

P Wild, E M Schraner, E Eggenberger

    Biology of the Cell
    |January 1, 1984
    PubMed
    Summary
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    Parathyroid glands release parathyroid hormone via exocytosis when calcium levels drop. Membrane proteins are recycled back to the Golgi complex through endocytosis after secretion.

    Area of Science:

    • Endocrinology
    • Cell Biology
    • Physiology

    Background:

    • Parathyroid hormone (PTH) regulates calcium and phosphate homeostasis.
    • The secretory pathway of PTH involves exocytosis and endocytosis.

    Purpose of the Study:

    • To investigate the dynamic membrane changes in parathyroid glands during stimulated hormone secretion.
    • To elucidate the mechanisms of membrane trafficking in response to low serum calcium.

    Main Methods:

    • Rats were infused with EGTA to induce hypocalcemia.
    • Morphometric analysis was used to quantify cellular compartments and membrane surface areas.

    Main Results:

    • Within 1 hour of calcium depression, membrane shifted from secretory granules and Golgi to the plasma membrane.

    Related Experiment Videos

  • Between 1 and 3 hours, membrane shifted from the plasma membrane back to the Golgi complex.

    • Conclusions:

    • These membrane shifts suggest PTH release via exocytosis and subsequent plasma membrane retrieval by endocytosis.
    • The study highlights the dynamic membrane remodeling involved in regulated hormone secretion.