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Cardiovascular responses in the diabetic rat.

F Charocopos, H Gavras

    Quarterly Journal of Experimental Physiology (Cambridge, England)
    |July 1, 1984
    PubMed
    Summary

    Diabetic rats show reduced renal blood flow early in the disease process. Cardiac output decreases later, only in 15-week-old diabetic rats, indicating altered hemodynamics in diabetes.

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    Effect of a new angiotensin converting enzyme inhibitor MK 421 and its lysine analogue on the components of the renin system in healthy subjects. 1981.

    British journal of clinical pharmacology·2004

    Area of Science:

    • Physiology
    • Cardiovascular Research
    • Endocrinology

    Background:

    • Diabetes mellitus is a complex metabolic disorder affecting multiple organ systems.
    • Cardiovascular complications are a major cause of morbidity and mortality in diabetic patients.
    • Understanding haemodynamic changes in diabetes is crucial for early diagnosis and intervention.

    Purpose of the Study:

    • To investigate cardiac and regional haemodynamics in streptozotocin-induced diabetic rats at different disease stages.
    • To assess the impact of diabetes on cardiac output and renal blood flow.
    • To explore the role of plasma renin activity in diabetic haemodynamic alterations.

    Main Methods:

    • Comparative haemodynamic analysis in 12- and 15-week-old streptozotocin-diabetic rats versus non-diabetic controls.
    • Measurement of cardiac output, renal blood flow, and plasma renin activity.
    • Assessment of regional circulations in brain, heart, gastrointestinal, and musculocutaneous systems.

    Main Results:

    • Reduced cardiac output observed in 15-week-old diabetic rats (64 +/- 13 ml/min) but not in 12-week-old diabetic rats (104 +/- 25 ml/min).
    • Significantly decreased renal blood flow in both 12- and 15-week-old diabetic rats (3.4-3.7 ml/min.g) compared to controls (5.47 ml/min.g).
    • Elevated plasma renin activity in diabetic rats (16.6-19.3 ng/ml.h) compared to controls (4 ng/ml.h), partially explaining reduced renal flow.

    Conclusions:

    • Renal perfusion is impaired at an earlier stage of diabetes than cardiac output.
    • Haemodynamic alterations in diabetes are progressive, affecting cardiac output later in the disease.
    • Increased plasma renin activity contributes to altered renal haemodynamics in diabetic rats.

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