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Circulating immune complexes in regularly dialyzed patients with chronic renal failure
American Journal of Nephrology
|January 1, 1984
Summary
This study found a high prevalence of circulating immune complexes (CIC) in patients undergoing dialysis. These immune complexes were linked to other immunological issues but not directly to factors like age or infection.
Area of Science:
- Nephrology
- Immunology
- Clinical Chemistry
Background:
- Circulating immune complexes (CIC) are implicated in various autoimmune and renal diseases.
- Assessing CIC prevalence is crucial for understanding uremic patient complications.
Purpose of the Study:
- To investigate the prevalence of CIC in patients undergoing maintenance hemodialysis.
- To explore the relationship between CIC and other immunological markers in uremic patients.
Main Methods:
- Utilized the C1q binding assay (C1q BA) and conglutinin binding assay (Kg BA) to detect CIC.
- Analyzed data from 200 patients undergoing maintenance hemodialysis.
Main Results:
- Increased C1q binding detected in 45% of patients; elevated Kg BA in 31%.
- CIC prevalence was consistent across different dialysis modalities and renal disease types.
- CIC presence correlated with rheumatoid factor activity but not lymphocytotoxic antibodies.
Conclusions:
- Dialyzed uremic patients exhibit a high prevalence of CIC.
- CIC in uremia is associated with other immunological abnormalities, particularly rheumatoid factor.