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Related Experiment Videos

Muscle development in thyroidectomised chickens (Gallus domesticus).

G E Moore, S Harvey, H Klandorf

    General and Comparative Endocrinology
    |August 1, 1984
    PubMed
    Summary

    Hypothyroidism induced by thyroidectomy slows down fast-phasic muscle activity, affecting enzymes like myofibrillar ATPase and phosphorylase. Slow-tonic muscle activity remains unaffected in these hypothyroid cockerels.

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    Area of Science:

    • Muscle physiology
    • Endocrinology
    • Metabolic studies

    Background:

    • Thyroid hormones play a crucial role in regulating muscle metabolism and function.
    • Understanding the impact of hypothyroidism on different muscle types is essential for comprehending muscle pathophysiology.

    Purpose of the Study:

    • To investigate the effects of surgically induced hypothyroidism on muscle metabolic and contractile activity in immature cockerels.
    • To determine if hypothyroidism differentially affects fast-phasic and slow-tonic muscle types.

    Main Methods:

    • Surgical thyroidectomy was performed on 6-week-old cockerels.
    • Muscle samples were collected 4 weeks post-thyroidectomy.
    • Assays were conducted to measure Mg2+-activated myofibrillar ATPase and total phosphorylase activity.

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  • Muscle length and weight were also measured.

    • Main Results:

    • Hypothyroidism significantly reduced Mg2+-activated myofibrillar ATPase and total phosphorylase activity in fast-phasic muscles (posterior latissimus dorsi and scapulotriceps).
    • Enzyme activities in slow-tonic muscle (anterior latissimus dorsi) were not affected by thyroidectomy.
    • Thyroidectomy did not alter muscle length but reduced the weight of the anterior latissimus dorsi and scapulotriceps muscles.

    Conclusions:

    • Hypothyroidism leads to a decrease in the metabolic and contractile capacity of fast-phasic muscles.
    • Slow-tonic muscles appear to be resistant to the effects of hypothyroidism in terms of enzyme activity.
    • These findings highlight the differential impact of thyroid status on various skeletal muscle fiber types.