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Serum lactate dehydrogenase in detecting liver damage associated with pre-eclampsia
British Journal of Obstetrics and Gynaecology
|January 1, 1978
Summary
Serum enzymes like lactate dehydrogenase (LDH) and its hepatic fraction (LDH5) indicate liver damage in pre-eclampsia and eclampsia. Damage severity correlated with disease severity in pregnant patients.
Area of Science:
- Obstetrics and Gynecology
- Clinical Biochemistry
- Hepatology
Background:
- Preeclampsia and eclampsia are severe pregnancy complications.
- Liver dysfunction can occur in these conditions.
- Serum enzymes are potential biomarkers for liver injury.
Purpose of the Study:
- To assess liver damage in normal pregnancy, pre-eclampsia, and eclampsia.
- To evaluate the utility of lactate dehydrogenase (LDH) and its hepatic fraction (LDH5) as indicators of liver injury.
- To correlate enzyme levels with disease severity.
Main Methods:
- Serum samples were collected from 60 normal pregnant women, 20 patients with pre-eclampsia, and 10 with eclampsia.
- Lactate dehydrogenase (LDH) and its hepatic fraction (LDH5) were measured.
- Enzyme levels were compared across the groups and correlated with clinical severity.
Main Results:
- Elevated LDH and LDH5 levels were observed in patients with pre-eclampsia and eclampsia compared to normal pregnancies.
- LDH5 showed a stronger association with liver damage.
- A positive correlation was found between enzyme levels and the severity of pre-eclampsia and eclampsia.
Conclusions:
- Serum LDH and LDH5 are valuable biochemical markers for detecting liver damage in pre-eclampsia and eclampsia.
- LDH5 is a more specific indicator of hepatic injury in these conditions.
- Monitoring these enzymes can aid in assessing disease progression and severity.