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Related Experiment Videos

Acromegaly in the dog.

J E Eigenmann

    The Veterinary Clinics of North America. Small Animal Practice
    |July 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Canine acromegaly presents with soft tissue enlargement and respiratory stridor. Treatment involving progestagen withdrawal or ovariohysterectomy can significantly improve clinical signs and hormone levels.

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    Area of Science:

    • Veterinary Medicine
    • Endocrinology
    • Canine Health

    Background:

    • Canine acromegaly is characterized by excessive growth hormone (GH) production, often linked to progestagen administration or natural progesterone influence.
    • Clinical signs include soft tissue proliferation, leading to facial changes, abdominal enlargement, and respiratory stridor.

    Purpose of the Study:

    • To outline the characteristic clinical, radiographic, and biochemical findings in canine acromegaly.
    • To establish diagnostic criteria for acromegaly in dogs.
    • To investigate the role of progestagens and the effect of their withdrawal on GH levels and clinical signs.

    Main Methods:

    • Clinical examination and radiographic assessment for soft tissue changes.
    • Measurement of basal and potentially non-suppressible plasma growth hormone (GH) levels.

    Related Experiment Videos

  • Assay of GH-dependent insulin-like growth factor I (IGF-I) concentrations.
  • Evaluation of clinical response following progestagen withdrawal or ovariohysterectomy.

    • Main Results:

    • Characteristic findings include soft tissue mass increase (orolingual, oropharyngeal, orolaryngeal), skin folds, abdominal enlargement, and respiratory stridor.
    • Hyperglycemia, PU/PD, elevated serum alkaline phosphatase (SAP), and lowered packed cell volume (PCV) may be present.
    • Elevated basal plasma GH and drastically elevated GH-dependent insulin-like growth factor I are diagnostic hallmarks.
    • Progestagen withdrawal or ovariohysterectomy led to reduced GH and IGF-I levels and clinical improvement.

    Conclusions:

    • Canine acromegaly diagnosis relies on identifying characteristic physical changes and confirming elevated GH and IGF-I levels.
    • Progestagen influence is a key factor in the development of acromegaly in susceptible female dogs.
    • Therapeutic interventions targeting progestagen withdrawal can effectively manage canine acromegaly.