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Related Experiment Videos

Relation between electrocardiographic repolarisation changes and mechanical events in left ventricular hypertrophy.

R B Moore, L M Shapiro, D G Gibson

    British Heart Journal
    |November 1, 1984
    PubMed
    Summary

    Electrocardiographic "strain" in left ventricular hypertrophy is linked to impaired early diastolic relaxation, not systolic dysfunction. Abnormal electrical recovery in these patients may occur independently of other factors.

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    Area of Science:

    • Cardiology
    • Physiology

    Background:

    • Left ventricular hypertrophy (LVH) can affect ventricular function.
    • Electrocardiographic (ECG)
    • strain
    • patterns are observed in some LVH patients.

    Purpose of the Study:

    • To investigate the relationship between ECG
    • strain
    • and ventricular function in patients with LVH.
    • To differentiate electrical abnormalities from mechanical dysfunction.

    Main Methods:

    • Utilized digitized M-mode echocardiography and 12-lead ECGs.
    • Studied 64 patients with pressure overload LVH, 21 with hypertrophic cardiomyopathy, and 14 athletes.

    Main Results:

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    • Patients with ECG
    • strain
    • exhibited prolonged diastolic intervals and reduced early diastolic wall thinning.
    • Systolic function (fractional shortening, peak velocity of circumferential fibre shortening) was normal in both strain and non-strain groups.
    • Athletes showed shorter electromechanical systole with synchronous T wave termination and minimum cavity dimension.

    Conclusions:

    • Abnormal electrical recovery in LVH is closely associated with impaired early diastolic relaxation.
    • This impaired relaxation can be dissociated from systolic function, cavity dimension, and increased myocardial mass.
    • The normal relationship between electrical and mechanical systole is maintained even with reversed repolarization polarity.