[Disordered meiosis in sterile male mice in a Lati:CFLP colony]

The incidence rate of sterile male mice in a Lati:CFLP colony was studied. It was established to amount to 0.33 +/- 011%. Part of sterile males (about 64%) had reduced weight testicles. Cytological analysis revealed spermatogenesis blockade because of spermatocyte death in the late prophase and metaphase I meiosis in these animals. It is concluded that in the mouse colony under study, genetic factor (chromosome rearrangement or gene mutation) is maintained, which determines meiosis blockade in male mice-bearers of this factor.