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Krestin (PSK).

S Tsukagoshi, Y Hashimoto, G Fujii

    Cancer Treatment Reviews
    |June 1, 1984
    PubMed
    Summary

    Polysaccharide K (PSK), derived from Coriolus versicolor, demonstrated effectiveness against animal tumors and in cancer patients. PSK administration restored immune responses and enhanced killer T cell activity, correlating with antitumor effects.

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    Area of Science:

    • Immunology
    • Pharmacology
    • Mycology

    Background:

    • Polysaccharide K (PSK), a preparation from Coriolus versicolor, contains glucan and protein.
    • PSK has shown efficacy in preclinical tumor models and clinical cancer treatment.
    • Tumor-bearing hosts often exhibit altered immune responses, impacting treatment outcomes.

    Purpose of the Study:

    • To investigate the immunomodulatory effects of PSK in cancer.
    • To explore the correlation between PSK's antitumor activity and immune cell function.
    • To understand the mechanism of PSK's action, including its interaction with immunosuppressive factors.

    Main Methods:

    • Administration of PSK to tumor-bearing animals and cancer patients.
    • Assessment of various immune responses, including killer T cell activity.
    • In vitro studies to examine PSK's interaction with immunosuppressive substances.
    • Pharmacokinetic studies using radiolabeled PSK in rats.

    Main Results:

    • PSK demonstrated antitumor effects in allogeneic and syngeneic animal tumor models.
    • Oral PSK administration restored suppressed immune responses in tumor-bearing animals.
    • PSK enhanced killer T cell activity in tumor-bearing mice, correlating with antitumor efficacy.
    • PSK competed with immunosuppressive substances and modulated the intestinal immune system.

    Conclusions:

    • PSK exhibits significant antitumor properties through immunomodulation.
    • PSK's ability to restore immune balance and enhance cytotoxic T cells is key to its efficacy.
    • The intestinal immune system plays a role in PSK's therapeutic effects, with oral administration leading to systemic absorption of breakdown products.

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