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Fibrinolysis--a review.

Annals of Clinical and Laboratory Science

|November 1, 1984

Summary

This summary is machine-generated.

Fibrinolysis dissolves blood clots using plasmin. Therapeutic agents like streptokinase and urokinase activate plasminogen, proving more effective than anticoagulation for deep vein thrombi and pulmonary emboli.

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Area of Science:

Biochemistry
Hematology
Pharmacology

Background:

Fibrinolysis is the physiological process of dissolving fibrin clots.
Plasmin, a glycoprotein, is the primary enzyme responsible for clot dissolution.
Plasminogen activation to plasmin is naturally mediated by tissue plasminogen activator (TPA) on fibrin surfaces.

Purpose of the Study:

To review the mechanism and therapeutic applications of fibrinolysis.
To compare the efficacy of fibrinolytic therapy with anticoagulation.
To discuss laboratory monitoring during fibrinolytic therapy.

Main Methods:

Review of the fibrinolytic system and its activators.
Comparison of therapeutic outcomes between fibrinolytic agents and anticoagulants.

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Analysis of laboratory parameters indicative of fibrinolysis.

Main Results:

Tissue plasminogen activator (TPA) is available for limited therapeutic use.
Streptokinase and urokinase are commonly used to activate plasminogen therapeutically.
Fibrinolytic therapy demonstrates superior efficacy over anticoagulation for deep vein thrombi and pulmonary emboli.

Conclusions:

Therapeutic fibrinolysis involves plasminogen activation, leading to clot dissolution.
Laboratory monitoring during fibrinolytic therapy reveals changes in clotting factors and inhibitors.
Clinical correlation with laboratory findings is crucial for effective patient management.