Excess granulation tissue responses associated with isotretinoin therapy

Area of Science:

• Dermatology
• Histopathology
• Tissue Engineering

Background:

• Isotretinoin is a widely prescribed oral retinoid for severe acne vulgaris.
• Acne treatments can sometimes present with unexpected side effects.
• Granulation tissue formation is a complex biological process.

Observation:

• Two patients on isotretinoin therapy developed multiple polypoid lesions.
• These lesions histologically showed granulation tissue.
• An increase in non-sulphated acid mucopolysaccharides was noted in the stroma.

Findings:

• Histological examination revealed excess non-sulphated acid mucopolysaccharides in granulation tissue stroma.
• Lesions demonstrated polypoid projections.
• Complete resolution was achieved through curettage and/or chemical cautery.

Implications:

• Isotretinoin may play a role in the development of these specific granulation tissue lesions.
• Understanding the mechanism of mucopolysaccharide accumulation is crucial.
• Further research is needed to elucidate the link between isotretinoin and granulation tissue formation.