Related Experiment Videos
Immunological typing of acute lymphoblastic leukaemia patients in Singapore--a preliminary experience
Six new patients with acute lymphoblastic leukaemia (ALL) have been studied with a battery of cell surface marker assays. These included T cell enumeration, B cell enumeration, monoclonal antibody studies for T cell subsets, (T helper cells, T suppressor cells and mature peripheral total T cells), HLA--DR (Ia-like antigens) and common ALL antigen. Three patients were found to have common ALL, 2 had null cell ALL and one had T cell ALL. Cytochemical studies on these 6 patients demonstrated a positive correlation between E rosette positivity and focal paranuclear staining with acid phosphatase. There appeared to be no correlation between FAB morphology and immunological subtype in the 6 patients studied.
Six new patients with acute lymphoblastic leukaemia (ALL) have been studied with a battery of cell surface marker assays. These included T cell enumeration, B cell enumeration, monoclonal antibody studies for T cell subsets, (T helper cells, T suppressor cells and mature peripheral total T cells), HLA--DR (Ia-like antigens) and common ALL antigen. Three patients were found to have common ALL, 2 had null cell ALL and one had T cell ALL. Cytochemical studies on these 6 patients demonstrated a positive correlation between E rosette positivity and focal paranuclear staining with acid phosphatase. There appeared to be no correlation between FAB morphology and immunological subtype in the 6 patients studied.