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Related Experiment Videos

Mannose-specific oligosaccharide recognition by mononuclear phagocytes.

P D Stahl, T E Wileman, S Diment

    Biology of the Cell
    |January 1, 1984
    PubMed
    Summary

    Macrophages use mannose receptors to recognize specific glycoproteins. These receptors are regulated, with activated macrophages showing reduced activity, and they recycle through an acidic compartment.

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    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • Macrophages play a key role in the immune system.
    • Mannose-terminated glycoproteins are important targets for cellular recognition.

    Purpose of the Study:

    • To investigate the regulation and characteristics of the mannose receptor on macrophages.
    • To understand the cellular trafficking of the mannose receptor.

    Main Methods:

    • Kinetic experiments were used to study receptor recycling.
    • Fractionation techniques were employed to analyze receptor localization.

    Main Results:

    • Mannose receptor expression is tightly regulated on macrophages.
    • Activated macrophages exhibit low mannose receptor activity.

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  • Cell surface mannose receptors appear to recycle via an acidic, pre-lysosomal compartment.
  • The mannose receptor is likely a large polypeptide, structurally similar to serum mannose-binding protein.

    • Conclusions:

    • The mannose receptor is a dynamic entity involved in cellular processes.
    • Potential roles include regulating extracellular lysosomal hydrolase levels.