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An epidemiological study of Hirschsprung's disease
International Journal of Epidemiology
|December 1, 1984
Summary
Hirschsprung's disease incidence is 18.6 per 100,000 livebirths, with higher rates in males and non-whites. Genetic factors, like Down's Syndrome, may play a role in Hirschsprung's disease etiology.
Area of Science:
- Pediatric Epidemiology
- Medical Genetics
- Congenital Disorders
Background:
- Hirschsprung's disease (HSCR) is a congenital anomaly affecting the large intestine.
- Understanding HSCR incidence and risk factors is crucial for public health and clinical management.
Purpose of the Study:
- To determine the incidence of Hirschsprung's disease in Baltimore.
- To investigate potential genetic and environmental risk factors for HSCR.
Main Methods:
- Retrospective cohort study identifying HSCR cases diagnosed between 1969-1977.
- Data collection through hospital records and death certificates.
- Incidence rates calculated per 100,000 livebirths, stratified by sex and race.
Main Results:
- Overall incidence was 18.6 per 100,000 livebirths.
- Male to female ratio was 4.32:1; non-white to white ratio was 1.67:1.
- Non-white males exhibited the highest incidence (37.6 per 100,000 livebirths); 9% of cases had Down's Syndrome.
Conclusions:
- Findings suggest a potential genetic component in HSCR etiology.
- No significant environmental trends or socioeconomic links were identified.
- Further research into micro-environmental factors is recommended for Hirschsprung's disease.