[Incidence and severity of cutaneous adverse effects of drugs]

The frequency of adverse cutaneous reactions to drugs is generally overestimated in important prospective studies. Nevertheless, the responsibility of some drugs considered as allergenic (Allopurinol, nonsteroidal anti-inflammatory drugs) appears to be underestimated. The type of eruption, its topography and duration are the most important criteria of severity. In the Geneva University Clinic of Dermatology, adverse cutaneous reactions to drugs occurred (mean of 6 years) in 1,2 p. 100 of all outpatients and in 4,4 p. 100 of all inpatients. The disease was severe in 9 p. 100 of patients hospitalized for adverse cutaneous reaction to drugs.