A trial manufacture of a motor-driven laser light scattering optic for whole bladder wall irradiation

The detection of CIS of the bladder by fluorescence endoscopy with hematoporphyrin derivative (HpD) and argon ion laser was performed using a video monitoring system coupling with an image intensifier; however, it was difficult because of the reflecting light of the excitation light. Whole bladder wall photoradiation therapy was carried out in 3 patients with multicentric CIS of the bladder, using argon-dye laser light (630 +/- 1.6 nm) of 5 to 25 J/cm2. The anticancer effect of this therapy was followed by urinary cytology and clusters of vacuolated cancer cells were observed for 2 days after the therapy.