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Interaction of H-2Db with mutant histocompatibility gene H (KH-11) in the mouse

R W Melvold1, H I Kohn, D W Bailey

  • 1Department of Radiation Therapy, Harvard Medical School, Boston, Massachusetts.

Immunogenetics
|January 1, 1980
PubMed

The detectable presence of H (KH-11)b, a mutant non-H-2 histocompatibility gene, was previously shown to depend upon the simultaneous presence, in the skin-graft donor, of both the mutant gene and the H-2b haplotype. The experiments reported here demonstrate that H-2Db is the essential element of H-2b for this interaction. Of two H-2Db histocompatibility mutations, H-2bm13 can replace H-2Db in this interaction, but H-2bm14 cannot.

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