Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Muscle spindle function in organophosphorus neuropathy.

T Baker, H E Lowndes

    Brain Research
    |March 3, 1980
    PubMed
    Summary

    Muscle spindle dysfunction contributes to neurological signs in organophosphorus neuropathy. This study in cats reveals sensory and motor impairments underlie the condition, with function recovering over time.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Black Hole Spectroscopy and Tests of General Relativity with GW250114.

    Physical review letters·2026
    Same author

    Safety of Immune Checkpoint Inhibitors Prior to Liver Transplantation in Hepatocellular Carcinoma.

    Alimentary pharmacology & therapeutics·2026
    Same author

    GW250114: Testing Hawking's Area Law and the Kerr Nature of Black Holes.

    Physical review letters·2025
    Same author

    Amplifying walking activity in Parkinson's disease through autonomous music-based rhythmic auditory stimulation: randomized controlled trial.

    NPJ Parkinson's disease·2025
    Same author

    Biomarkers for the diagnosis and treatment of rheumatoid arthritis - a systematic review.

    Postgraduate medicine·2022
    Same author

    Pragmatic sedation strategies to prevent secondary brain injury in low-resource settings.

    Anaesthesia·2022

    Area of Science:

    • Neuroscience
    • Toxicology
    • Muscle Physiology

    Background:

    • Organophosphorus compounds cause delayed neuropathy, affecting motor function.
    • Neurological signs include high-step gait and reduced response to stimuli.
    • Muscle spindles are sensory receptors crucial for proprioception and motor control.

    Purpose of the Study:

    • To investigate the role of muscle spindle dysfunction in organophosphorus neuropathy.
    • To characterize the temporal profile of sensory nerve dysfunction following diisopropylfluorophosphate (DFP) exposure.
    • To determine the contribution of sensory impairment to the observed neurological deficits.

    Main Methods:

    • Cats were administered diisopropylfluorophosphate (DFP) via intra-arterial injection.
    • Soleus muscle spindle function was assessed at various time points post-injection.
    • Position sensitivities and thresholds of primary and secondary muscle spindle endings were measured.

    Main Results:

    • Muscle spindle dysfunction, particularly in secondary endings, appeared 14 days post-DFP.
    • By 21 days, both primary and secondary endings showed reduced sensitivity and increased thresholds.
    • Spindle function normalized by 56 days, mirroring alpha-motor axon recovery.

    Conclusions:

    • Muscle spindle dysfunction is a key component of organophosphorus neuropathy.
    • Both sensory (spindle) and motor (axon) impairments contribute to the clinical signs.
    • The findings highlight the mixed sensory-motor nature of this neurotoxic condition.

    Related Experiment Videos