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Neutralization of the effect of delta 9-tetrahydrocannabinol on barbiturate sleeping time by specific active
Drug and Alcohol Dependence
|March 1, 1980
Abstract:
Adult mice were actively immunized with delta 9-tetrahydrocannabinol-bovine serum albumin (delta 9-THC-BSA) conjugate. Control animals were immunized with BSA alone. While the administration of pentobarbital and delta 9-THC to control animals resulted in the well known prolongation of the barbiturate sleeping time, in mice immunized with delta 9-THC-BSA conjugate this effect was almost completely neutralized.