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Adrenocorticotropin release by tryptophan in man
The Journal of Clinical Endocrinology and Metabolism
|February 1, 1980
Summary
Tryptophan administration significantly elevates cortisol and adrenocorticotropic hormone (ACTH) levels. This suggests tryptophan stimulates ACTH release, potentially via the central serotonergic nervous system.
Area of Science:
- Neuroendocrinology
- Biochemistry
Background:
- Previous studies indicated tryptophan administration elevates cortisol.
- The current study aimed to confirm this and investigate the effect on ACTH.
Purpose of the Study:
- To confirm tryptophan's effect on cortisol.
- To investigate tryptophan's effect on ACTH release.
- To explore the relationship between tryptophan, ACTH, and cortisol.
Main Methods:
- Administration of tryptophan to subjects.
- Measurement of cortisol levels.
- Measurement of ACTH levels.
Main Results:
- Cortisol levels increased significantly (12.4 +/- 5.2 microgram/dl, P < 0.02).
- ACTH levels rose significantly in responding patients (101.8 +/- 45.8% above baseline).
- ACTH and cortisol changes were closely correlated (r = 0.81, P < 0.01).
Conclusions:
- Tryptophan administration stimulates ACTH release.
- This stimulation may involve the central serotonergic nervous system.
- High tryptophan levels may stimulate ACTH, while lower levels might inhibit it.