[Effect of bonaphthone on embryogenesis in white rats and mice]

Results of testing the embryotropic activity of bonaphthone used in different doses (700; 400; 100; 50 and 2 mg/kg) are reported. With its oral introduction to pregnant rats bonaphthone, given in doses at the level of the therapeutid one (2 mg/kg) and exceeding it by as much as 25 times (50 mg/kg), was found not to produce any damaging effect on the fetus. With its action in doses of 100 and 400 mg/kg a slight embryotoxic effect was noted. In the sublethal dose of 700 mg/kg the preparation displays a moderate embryotoxic action and produces a number of circulatory changes in the fetuses. It is concluded that bonaphthone displays no teratogenic properties.