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Varicella dendritic keratitis.

Y Uchida, M Kaneko, K Hayashi

    American Journal of Ophthalmology
    |February 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Varicella-zoster virus (VZV) can cause serious eye complications in children, including disciform keratitis and iritis. This study identified VZV in dendritic corneal lesions that developed in children previously diagnosed with varicella.

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    Area of Science:

    • Ophthalmology
    • Virology
    • Pediatrics

    Background:

    • Varicella (chickenpox) is a common childhood viral infection.
    • Ocular complications of varicella, such as keratitis and iritis, can occur.
    • Herpes zoster ophthalmicus is a reactivation of the varicella-zoster virus.

    Observation:

    • Two children presented with unilateral disciform keratitis and iritis following varicella infection.
    • Dendritic corneal lesions, characteristic of herpes zoster, appeared four months after the initial varicella rash.
    • Standard treatments for varicella eye complications were administered.

    Findings:

    • Varicella-zoster virus (VZV) antigen was detected in corneal epithelial cells from the dendritic lesions using direct immunofluorescence.
    • This confirms VZV as the causative agent of the late-onset ocular lesions.

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    Implications:

    • Varicella-zoster virus can cause delayed and severe ocular manifestations beyond the primary infection.
    • Ophthalmologists should consider VZV reactivation in children presenting with atypical corneal lesions after varicella.
    • Early diagnosis and appropriate antiviral therapy are crucial for managing VZV-related eye disease.