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Untreated acrodermatitis enteropathica in adults.

P Olholm-Larsen

    Dermatologica
    |January 1, 1978
    PubMed
    Summary

    Acrodermatitis enteropathica (AE) can persist into adulthood with fluctuating or subtle symptoms. Low serum zinc levels are key diagnostic indicators in adult AE cases, suggesting potential underdiagnosis.

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    Area of Science:

    • Dermatology
    • Genetics
    • Internal Medicine

    Background:

    • Acrodermatitis enteropathica (AE) is a rare genetic disorder of zinc absorption.
    • While typically diagnosed in childhood, AE can persist into or manifest in adulthood.

    Observation:

    • This study reports two adult cases of AE with varied symptom presentation.
    • Symptoms included persistent skin lesions, gastrointestinal issues, depression, and parkinsonism.
    • Low serum zinc levels were a consistent diagnostic marker across both cases.

    Findings:

    • Adult AE cases may exhibit uncharacteristic or fluctuating symptomatology, differing from childhood presentations.
    • Disease remission or significant symptom reduction can occur at puberty or in adulthood.
    • Neurological and psychiatric symptoms like depression and parkinsonism can be associated with adult AE.

    Implications:

    • Adult AE may be underdiagnosed due to its atypical presentation.
    • Maintaining awareness of AE in adults with unexplained skin, gastrointestinal, or neurological symptoms is crucial.
    • Monitoring serum zinc levels is essential for diagnosing and managing AE in adult patients.

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