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Adult pulmonary cytomegalic inclusion disease: report of a case
Journal of Clinical Pathology
|January 1, 1980
Abstract:
A case is presented of pulmonary cytomegalic inclusion disease in adult. The condition was only diagnosed post mortem. A detailed description of the inclusions and inclusion-bearing cells is given. Histochemical observations which reveal an outer and inner zone to the intranuclear inclusion body are confirmed. Electron microscopy shows the viral basis of the infection. The morphology of the virus particles is compatible with a herpesvirus infection.
Insights
Pulmonary cytomegalic inclusion disease, a rare adult condition, was diagnosed post mortem. Electron microscopy confirmed a herpesvirus infection, revealing characteristic viral morphology.
Area of Science:
- Pathology
- Virology
- Pulmonary Medicine
Background:
- Cytomegalic inclusion disease (CID) is a viral infection typically seen in neonates.
- Pulmonary involvement in adults is rare and often diagnosed late.
Observation:
- A post-mortem diagnosis of pulmonary cytomegalic inclusion disease in an adult.
- Detailed morphological description of intranuclear inclusions and inclusion-bearing cells.
- Histochemical analysis confirmed distinct zones within the intranuclear inclusions.
Findings:
- Electron microscopy identified viral particles consistent with herpesvirus.
- The study confirmed the viral etiology of the observed pulmonary pathology.
- Morphological characteristics supported classification as a herpesvirus infection.
Implications:
- Highlights the importance of considering cytomegalic inclusion disease in adult pulmonary pathology, even if rare.
- Electron microscopy and histochemistry are crucial for definitive diagnosis.
- Understanding the viral morphology aids in classifying the infection within the herpesvirus family.