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Related Experiment Videos

Biopsy for microcalcification detected by mammography.

D F Roses, M N Harris, F Gorstein

    Surgery
    |March 1, 1980
    PubMed
    Summary

    Mammography clustered microcalcifications can indicate breast cancer. Precise localization and removal of calcifications are crucial to avoid missing adjacent carcinomas in biopsies.

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    Area of Science:

    • Radiology
    • Oncology
    • Pathology

    Background:

    • Mammography is a key tool for breast cancer screening.
    • Clustered microcalcifications without a visible mass present a diagnostic challenge.
    • Biopsies are performed to investigate suspicious microcalcifications.

    Purpose of the Study:

    • To evaluate the diagnostic yield of biopsying clustered microcalcifications detected on mammography.
    • To assess the relationship between microcalcifications and underlying malignancy.
    • To determine the adequacy of current biopsy techniques.

    Main Methods:

    • Fifty-two patients with mammographically detected clustered microcalcifications underwent biopsy.
    • Microcalcification localization was achieved using mammographic views and measurements.
    • Specimen radiography confirmed the inclusion of microcalcifications in the biopsy sample.

    Main Results:

    • Carcinoma was detected in 17 out of 52 patients (33%).
    • In four cases (24%), microcalcifications were associated with fibrocystic disease, with carcinoma found in adjacent tissue.
    • Inadequate margin excision during biopsy may lead to missed adjacent carcinomas.

    Conclusions:

    • Clustered microcalcifications are a significant indicator of breast cancer.
    • Precise localization and complete removal of the microcalcified area are essential for accurate diagnosis.
    • Careful surgical technique is required to avoid excluding adjacent malignant tissue during biopsy.

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