Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Abnormal bone histology in idiopathic hypercalciuria.

H H Malluche, W Tschoepe, E Ritz

    The Journal of Clinical Endocrinology and Metabolism
    |April 1, 1980
    PubMed
    Summary

    Patients with hyperabsorptive hypercalciuria and kidney stones show reduced bone formation. Bone histology reveals decreased osteoblast activity and impaired mineralization, suggesting altered bone metabolism in these individuals.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    De novo glomerulonephritis in patients during remission from Wegener's granulomatosis.

    Clinical nephrology·1992
    Same author

    Reduced capillary density in the myocardium of uremic rats--a stereological study.

    Kidney international·1992
    Same author

    Renal histology in polycystic kidney disease with incipient and advanced renal failure.

    Kidney international·1992
    Same author

    The effect of uninephrectomy on progression of renal failure in autosomal dominant polycystic kidney disease.

    Journal of the American Society of Nephrology : JASN·1992
    Same author

    Severe hemorrhagic complications from infection with nephropathia epidemica strain of Hantavirus.

    Clinical nephrology·1992
    Same author

    Disturbed calcium metabolism in renal failure--pathogenesis and therapeutic strategies.

    Kidney international. Supplement·1992

    Area of Science:

    • Nephrology
    • Endocrinology
    • Bone Biology

    Background:

    • Idiopathic hypercalciuria with recurrent calcium oxalate stones is common.
    • The underlying bone metabolism in absorptive hypercalciuria is not fully understood.

    Purpose of the Study:

    • To investigate bone histology and cellular activity in patients with absorptive hypercalciuria and kidney stones.

    Main Methods:

    • Iliac crest bone biopsies from 15 patients were analyzed using quantitative histomorphometry.
    • Undecalcified sections were examined with fluorescent microscopy after tetracycline labeling.
    • Urinary calcium and cAMP excretion were measured under basal and stimulated conditions.

    Main Results:

    • Osteoclastic resorption was normal or low.

    Related Experiment Videos

  • Increased inactive osteoid and decreased osteoblastic activity were observed.
  • Reduced mineralization rate and diminished bone matrix apposition were evident.

    • Conclusions:

    • Patients with absorptive hypercalciuria exhibit impaired bone formation, characterized by reduced osteoblast function and delayed mineralization.
    • These bone changes may be linked to the pathophysiology of hypercalciuria and stone formation.