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Related Experiment Videos

Selfish genes, the phenotype paradigm and genome evolution.

W F Doolittle, C Sapienza

    Nature
    |April 17, 1980
    PubMed
    Summary

    Natural selection can create DNA sequences that only serve to replicate themselves within genomes. These non-phenotypic DNA elements, like transposable elements, do not require assigned evolutionary functions.

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    Area of Science:

    • Genomics
    • Molecular Biology
    • Evolutionary Biology

    Background:

    • Genomes contain DNA sequences with unknown functions.
    • The role of natural selection in shaping genomic content is a key area of study.

    Purpose of the Study:

    • To propose that natural selection can favor DNA sequences solely for their own survival within the genome.
    • To re-evaluate the functional necessity of certain repetitive DNA sequences.

    Main Methods:

    • Conceptual analysis of genomic elements.
    • Review of existing literature on transposable elements and repetitive sequences.

    Main Results:

    • Natural selection can lead to the emergence of DNA sequences lacking phenotypic expression.
    • These non-phenotypic DNA sequences primarily function in their own propagation within the genome.

    Conclusions:

    • Prokaryotic transposable elements and eukaryotic middle-repetitive sequences can be understood as DNA with intrinsic survival 'functions'.
    • Assigning specific phenotypic or evolutionary functions to these elements may not be necessary.

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