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Related Experiment Videos

Lymph node invasion and prognosis in nephroblastoma.

B Jereb, M F Tournade, J Lemerle

    Cancer
    |April 1, 1980
    PubMed
    Summary

    Metastatic lymph node involvement in Wilms tumor (nephroblastoma) significantly worsens patient outcomes. Radical lymph node dissection did not improve cure rates or reduce recurrence in these pediatric cancer cases.

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    The pathology of Wilms' tumour (nephroblastoma): the International Society of Paediatric Oncology approach.

    Journal of clinical pathology·2009

    Area of Science:

    • Pediatric Oncology
    • Surgical Oncology
    • Clinical Pathology

    Background:

    • Wilms tumor (nephroblastoma) is a common pediatric kidney cancer.
    • Prognostic factors are crucial for tailoring treatment strategies.
    • The role of lymph node metastasis in Wilms tumor requires further clarification.

    Purpose of the Study:

    • To evaluate the prognostic significance of lymph node metastasis in children with Wilms tumor.
    • To determine the impact of lymph node involvement on disease-free and overall survival.
    • To assess the efficacy of radical lymph node dissection in managing lymph node-positive Wilms tumor.

    Main Methods:

    • Analysis of 512 children with Wilms tumor Stages I-III from the SIOP nephroblastoma trial.
    • Microscopic examination of lymph nodes from 300 patients to identify metastatic invasion.

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  • Comparison of survival rates and recurrence patterns between patients with and without lymph node metastases.

    • Main Results:

    • Malignant lymph node invasion was detected in 15% of examined cases.
    • Patients with metastatic lymph node involvement exhibited significantly poorer disease-free and actuarial survival rates.
    • Radical lymph node dissection did not enhance cure rates or reduce abdominal recurrence in patients with lymph node metastases.

    Conclusions:

    • Lymph node metastasis is a significant negative prognostic indicator in pediatric Wilms tumor.
    • Current evidence does not support radical lymph node dissection as a beneficial intervention for improving outcomes in lymph node-positive Wilms tumor.
    • Further research may explore alternative or adjuvant therapies for patients with lymph node involvement.