The effects of epidermal growth factor on the cyclic nucleotide system in pig epidermis

Incubation of pig skin slices with epidermal growth factor (EGF) caused an increase in intracellular cyclic GMP concentration. A significant increase was found after 1 hr of incubation and reached a peak by 6 hr. EGF caused no change in the cyclic AMP level nor did it affect epinephrine-induced cyclic AMP responses.