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[Experimental studies into syncarcinogenesis. 7th communication: Syncarcinogenic effects of polycylic aromatic
Zeitschrift Fur Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology
|September 24, 1976
Abstract:
A mixture of 11 carcinogenic and noncarcinogenic hydrocarbons was applied to the shorn skin of the back of 3400 female NMRI-mice. The proportion of the hydrocarbons in the mixture corresponded to the analytical findings in condensates of cigarette smoke, automobil exhaust gas, and preservation curing smoke and tar. Antagonistic effects by the individual hydrocarbons in the mixture were not observed, on the contrary the substances in the mixture showed additive effects. There were no differences in the mode of action of the different mixtures.