Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polyamines in encephalomyocarditis virus.

S L Sheppard, A T Burness, S M Boyle

    Journal of Virology
    |April 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Encephalomyocarditis virus contains polyamines like putrescine, spermidine, and spermine. These molecules neutralize a portion of the viral genome, with varying proportions found in host tumor cells.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Whole genome sequencing-powered ctDNA sequencing for breast cancer detection.

    Annals of oncology : official journal of the European Society for Medical Oncology·2025
    Same author

    Development of an auxotrophic, live-attenuated Brucella suis vaccine strain capable of expressing multimeric GnRH.

    Vaccine·2019
    Same author

    Donor-Derived Metastatic Melanoma and Checkpoint Inhibition.

    Transplantation proceedings·2017
    Same author

    Low rates of vaccination in listed kidney transplant candidates.

    Transplant infectious disease : an official journal of the Transplantation Society·2015
    Same author

    Immunotherapeutics to prevent the replication of Brucella in a treatment failure mouse model.

    Vaccine·2014
    Same author

    The first detection of Brucella canis in cattle in the Republic of Korea.

    Zoonoses and public health·2012
    Same journal

    Something old, something new? Herpesvirus genome packaging examined in light of lessons from the tailed bacteriophages.

    Journal of virology·2026
    Same journal

    Receptor profiling and growth assessment of influenza A virus in porcine mammary and non-mammary tissues and derived cells.

    Journal of virology·2026
    Same journal

    Live human metapneumovirus vaccine candidates attenuated by temperature sensitivity mutations from human respiratory syncytial virus.

    Journal of virology·2026
    Same journal

    Structure and functional analyses of vaccinia virus J5 protein reveal distinct determinants for entry-fusion complex assembly and activation.

    Journal of virology·2026
    Same journal

    Coronavirus membrane protein with a fluorescent protein tag enables particle tracking for the study of virus assembly and egress in live cells.

    Journal of virology·2026
    Same journal

    Disruption of the S1/S2 multibasic cleavage site attenuates infectious bronchitis virus, while S2' partially restores viral virulence and expands tissue tropism.

    Journal of virology·2026
    See all related articles

    Area of Science:

    • Virology
    • Molecular Biology
    • Biochemistry

    Background:

    • Encephalomyocarditis virus (EMCV) is a significant pathogen.
    • Polyamines are essential cations involved in cellular processes.
    • Understanding viral-host interactions is crucial for virology research.

    Purpose of the Study:

    • To quantify polyamine content within EMCV particles.
    • To investigate the potential role of polyamines in viral genome neutralization.
    • To compare polyamine composition between the virus and its host cell.

    Main Methods:

    • Quantification of polyamines (putrescine, spermidine, spermine) in purified EMCV.
    • Assessment of the neutralizing capacity of these polyamines on the viral genome.
    • Analysis of polyamine profiles in Krebs ascites tumor cells.

    Related Experiment Videos

    Main Results:

    • EMCV contains approximately 200 putrescine, 100 spermidine, and 40 spermine molecules.
    • These polyamines can neutralize an estimated 11% of the viral genome.
    • The host Krebs ascites tumor cells exhibit different proportions of these polyamines.

    Conclusions:

    • Polyamines are integral components of EMCV, contributing to genome stability or neutralization.
    • The polyamine composition of EMCV reflects, in part, its host cell environment.
    • Further research is warranted to elucidate the precise mechanisms of polyamine-genome interaction in viruses.