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Metabolic adaptation in developing lung.

J B Warshaw, M L Terry, M B Ranis

    Pediatric Research
    |April 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    The developing rat lung uses glucose and fatty acids for energy. Fatty acid oxidation increases after birth, while glucose oxidation and pentose phosphate pathway activity decrease, indicating a shift in metabolic fuel sources.

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    Area of Science:

    • Biochemistry
    • Developmental Biology
    • Pulmonary Medicine

    Background:

    • The metabolic substrates utilized by the developing lung are not fully understood.
    • Understanding lung metabolic shifts is crucial for addressing respiratory development and diseases.

    Purpose of the Study:

    • To investigate the oxidative substrates used by the developing rat lung.
    • To characterize the postnatal changes in glucose and fatty acid metabolism in the lung.

    Main Methods:

    • Utilized rat lung slices for metabolic studies.
    • Measured CO2 production from glucose, palmitate, and caprate oxidation.
    • Assessed pentose phosphate pathway activity.
    • Quantified cytochrome oxidase and carnitine palmitoyltransferase activity.

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  • Determined palmitate incorporation into lipids.

    • Main Results:

    • The developing lung utilizes both glucose and fatty acids as oxidative substrates.
    • Glucose oxidation decreased at birth but increased after weaning; pentose phosphate pathway activity also decreased postnatally.
    • Fatty acid oxidation (palmitate, caprate) increased in the immediate postnatal period.
    • Enzymes involved in fatty acid oxidation, cytochrome oxidase and carnitine palmitoyltransferase, showed parallel increases.
    • Cytochrome oxidase activity in adult lung was significantly lower than in newborns.
    • Peak palmitate incorporation into lipids occurred during late fetal development.

    Conclusions:

    • The neonatal rat lung exhibits a significant reliance on fatty acid oxidation, with a shift away from glucose as a primary substrate shortly after birth.
    • Key enzymes supporting fatty acid metabolism are upregulated during the early postnatal period.
    • These findings highlight a critical metabolic transition in lung development crucial for respiratory function.