Related Experiment Video
Updated: Jul 27, 2026

07:01
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
[Cytology in single "cold" thyroid nodules (author's transl)].
Summary
This study analyzed 242 cold thyroid nodules, finding a high accuracy in diagnosing both malignancies and benign thyroid lesions through histocytologic correlations.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Thyroid nodules are common, and distinguishing between benign and malignant types is crucial for patient management.
- Cold nodules on scintigraphy require further investigation to determine their nature.
Purpose of the Study:
- To evaluate the diagnostic accuracy of histocytologic correlations for single cold thyroid nodules.
- To assess the effectiveness of this method in identifying thyroid malignancies and benign lesions.
Main Methods:
- Correlation of histocytologic findings with scintigraphic data for 242 single cold thyroid nodules.
- Analysis of diagnostic performance for malignancy and benignity.
Main Results:
- Histocytologic correlation demonstrated a 70.5% accuracy in identifying malignant thyroid nodules.
- The method achieved 91.8% accuracy in diagnosing benign thyroid lesions.
Conclusions:
- Histocytologic correlation is a valuable tool for the accurate diagnosis of cold thyroid nodules.
- This approach aids in differentiating between malignant and benign thyroid conditions, guiding treatment decisions.
Related Concept Videos
Polytene Chromosomes
Polytene chromosomes are giant interphase chromosomes with several DNA strands placed side by side. They were discovered in the year 1881 by Balbiani in salivary glands, intestine, muscles, malpighian tubules, and hypoderm of larvae Chironomus plumosus. Hence, these are also called "Salivary gland chromosomes." These are found in insects of the order Diptera and Collembola; in certain organs of mammals; and synergids, antipodes of flowering plants. Polytene chromosomes are also regularly...
The Nucleolus
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...

