[Complications after perhexiline maleate and amiodarone chlorhydrate treatment in a same patient: hypoglycemia, polyneuritis and hyperthyroidism (author's transl)]
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Abstract:
The authors report the case of a 65 year old man treated with amiodarone chlorhydrate since 4 years and perhexiline maleate since 15 months, admitted for constitutional symptoms with fever, neurologic troubles particularly polyneuritis and pronounced hypoglycemia. A diagnostic of hyperthyroidism was made and attributed to amiodarone. The hypoglycemia and the polyneuritis were related to perhexiline maleate as other signs presented by the patient. All the symptoms disappeared after discontinuation of the drugs. The complications secondary to maleate perhexiline administration are reviewed.
Insights
A 65-year-old man experienced hyperthyroidism from amiodarone and hypoglycemia with polyneuritis from perhexiline maleate. Drug withdrawal resolved all symptoms, highlighting potential adverse effects.
Area of Science:
- Cardiology
- Neurology
- Endocrinology
Background:
- A 65-year-old male patient was on long-term amiodarone hydrochloride and perhexiline maleate therapy.
- The patient presented with constitutional symptoms, fever, neurological issues, and severe hypoglycemia.
Observation:
- A diagnosis of amiodarone-induced hyperthyroidism was established.
- Hypoglycemia and polyneuritis were attributed to perhexiline maleate.
Findings:
- Discontinuation of both amiodarone hydrochloride and perhexiline maleate led to the complete resolution of all patient symptoms.
- This case highlights the distinct and potentially severe adverse effects of these two medications.
Implications:
- Clinicians should be vigilant for amiodarone-induced hyperthyroidism and perhexiline maleate toxicity, including hypoglycemia and polyneuritis.
- Careful patient monitoring and consideration of drug-induced complications are crucial in polypharmacy scenarios.
- Reviewing complications associated with perhexiline maleate is important for patient safety.